WHAT ARE ADJUVANTS?
ADJUVANTS CAN THE IMPROVE THE MAGNITUDE, BREADTH,
AND DURABILITY OF VACCINES
Boost magnitude of immune response
Problem: Antigens may fail to induce a sufficient immune response.
Solution: Adjuvants amplify the magnitude of the immune response to antigens.
Broaden immune cell recruitment/
Recruit broad spectrum of T cells
Problem: Vaccines may only respond to one variant of disease
Solution: Adjuvants can help broaden the breadth to the immune response to protect against other variants.
Extend durability of response
Problem: Vaccines often require frequent boosters to maintain protection as their effectiveness wanes over time.
Solution: Adjuvants can generate durable memory immune cells that can mount a long-lasting immune response against a pathogen, persisting for years after vaccination.
Improve tolerability and access
Problem: Antigen production can be costly or limited, and high doses may result in side effects.
Solution: Adjuvants enable a strong immune response with minimal antigen, increasing accessibility, decreasing costs, and improving vaccine tolerability.
WHAT IS QS-21 STIMULON™?
Case Study: Shingrix (contains STIMULON) vs. Zostavax
STIMULON increases both the activity and durability of vaccines
Reduction of risk of developing shingles (herpes zoster) within 3 years after vaccination
Reduction of risk of developing shingles at 8 years after vaccination
Sources: Shingrix PI, Zostavax PI, Stezova et al. Open Forum Infect Dis 2022; Baxter et al. Am J Epidemiol 2018
HOW IS SAPONIQX MAKING QS-21 STIMULON MORE ACCESSIBLE?
QS-21 STIMULON is scarce and expensive because of its dependence on an intricate and costly extraction process from the bark of a Chilean tree.
SaponiQx has developed an alternative method of producing QS-21 that doesn't rely on trees.
This innovation is designed to ensure a stable supply chain, uniform quality, scalable manufacturing, and reduced cost of goods.