Our Technology

WHAT ARE ADJUVANTS?

PATHOGENAAA

Antigens

Any foreign material that causes the body to mount a defensive immune response against that substance.

ADJUVANT

Adjuvant

Ingredient of a vaccine that helps create a stronger immune response in patients

A Better Vaccine

ADJUVANTS CAN THE IMPROVE THE MAGNITUDE, BREADTH,
AND DURABILITY OF VACCINES

Boost magnitude of immune response

Problem: Antigens may fail to induce a sufficient immune response.

Solution: Adjuvants amplify the magnitude of the immune response to antigens.

Broaden immune cell recruitment

Problem: Vaccines may only respond to one variant of disease

Solution: Adjuvants can help broaden the breadth to the immune response to protect against other variants.

Extend durability of response

Problem: Vaccines often require frequent boosters to maintain protection as their effectiveness wanes over time.

Solution: Adjuvants can generate durable memory immune cells that can mount a long-lasting immune response against a pathogen, persisting for years after vaccination.

Improve tolerability and access

Problem: Antigen production can be costly or limited, and high doses may result in side effects.

Solution: Adjuvants enable a strong immune response with minimal antigen, increasing accessibility, decreasing costs, and improving vaccine tolerability.

WHAT IS QS-21 STIMULON™?

QS-21 STIMULON is a proven adjuvant and key component of multiple approved vaccines, including Shingrix and Mosquirix

Case Study:  Shingrix (contains STIMULON) vs. Zostavax

STIMULON increases both the activity and durability of vaccines

Efficacy

Reduction of risk of developing shingles (herpes zoster) within 3 years after vaccination

0 %
0 %

Durability

Reduction of risk of developing shingles at 8 years after vaccination

0 %
0 %

Sources: Shingrix PI, Zostavax PI, Stezova et al. Open Forum Infect Dis 2022; Baxter et al. Am J Epidemiol 2018

HOW IS SAPONIQX MAKING STIMULON™ QS-21 MORE ACCESSIBLE?

Current
Manufacturing
Process

Access to QS-21 is limited and costly because of its dependence on natural resources and a complex supply chain, sourced from the bark of Chilean Quillaja Saponaria trees.

SaponiQx Manufacturing
Platform

SaponiQx has developed a sustainable method of producing QS-21 that doesn't rely on harvesting this natural resource.

This innovation is designed to ensure a stable supply chain, uniform quality, scalable manufacturing, and reduced cost of goods.